Industry Insights

  1. Cleaning pH Probes & Dissolved Oxygen Probes

    Q. Which Alconox, Inc. brand cleaner is well suited for cleaning pH and dissolved oxygen probes?

  2. Inorganic Residue Removal Via Clean In Place

    Q. We are a generic pharmaceutical manufacturer of Creams and Ointments. We are having difficulty cleaning equipment (specifically CIP) after making these types of products. We have been successful in cleaning 95% of our products using the alkaline detergent. We have couple of products that leave a white film after the cleaning cycles. These products do not contain metal oxides. We are planning to try the Citranox acid cleaner. Any suggestions?

  3. Detecting Residues In Cleaning Validation

    When beginning cleaning validation, a company must identify the residues to be tested and then select the best detection method. Alconox Inc. is here to help. We provide validation service support and we also provide technical support via Free Downloadable Whitepapers.

  4. Measuring Small-Beam MFD: Overcoming the Challenges

    Accurate beam size measurements for beam sizes under 10 μm are critical for many applications such as fiber optic coupling efficiency, defect scanning, optical design, and optical fabrication process control. The challenges for such a measurement include the use of focal plane arrays that are too large to reasonably profile without magnification, the high mechanical precision of the beam profiling apparatus, and the beams’ high divergences and rapid expansion. Reliable profiles for such small beams, however, can be obtained using near-field or far-field profiling techniques. This article presents and in-depth discussion of each technique, diagrams for their systems' set-up, and the benefits for using each one.

  5. Additive Manufacturing And 3D CAD

    The use of additive manufacturing and 3D CAD has modernized the way manufacturers design and build mechanical components. Additionally, direct metal laser melting (DMLM) and selective laser sintering (SLS or metal 3D printing) are quickly becoming the standard for customizable constructs that are system critical and are hard-to-fabricate. This article discusses the process of transforming a 3D CAD model into a mechanical component, as well as how to use a camera based beam profiling system to assist in achieving consistently accurate constructs.

  6. Select The Right Laser Power Sensor By Asking The Right Questions

    When the selection of a sensor turns out to be an incorrect choice, the system could procure inaccurate measurements, premature failure, and costly full disc replacement and recalibration. Even when the system setup seems straightforward, it is important to ask the correct questions in the decision making process to make sure that the chosen sensor meets the specifications of the system and application. This article presents three critical questions to ask before selecting a laser power sensor for a specific application.

  7. Trends In Drug Delivery- The Growth Of Cartridge Based Technology

    The use of cartridge-based drug delivery systems is projected to grow exponentially within traditional dental and insulin markets, as well as in therapeutic classes of drugs such as those that treat auto-immune diseases. There are several reasons for pharmaceutical companies to now select a cartridge-based system compared to a pre-filled syringe or vial such as enhanced support for long-term strategies and product differentiation in the market place.

  8. Why Connect An Auto-Injector To A Smartphone?

    No patient enjoys injecting themselves in order to monitor their blood sugar levels, so many drug delivery device manufacturers are continuously looking for the best forms of injection to make it easier for the patient. In light of the Internet of Things movement, the West-HealthPrize collaboration can now connect an auto-injector to software on a smartphone. But why would a patient want to connect their auto-injector to the Internet? This paper presents numerous benefits for a connected auto-injector including a redeemable point system, strengthened motivation, and immediate data collection and comparison.

  9. Extractables And Leachables – Assessing Risk In A Complex Landscape

    Within the medical device market, there is still confusion on the topics of extractable and leachable testing, as well as the process of making sense of and reporting the data to the regulatory authorities. This article offers an outlined process for extractable and leachable analysis which starts with the optimal component selection, assesses extractable information gaps and design fit, and defines the leachables testing plan.

  10. Six Tips For The Successful Integration Of Econsent

    Electronic informed consent (eConsent) represents a major improvement in the overall participant consenting process in clinical trials for investigation sites, sponsors and IRB/IECs. eConsent offers researchers numerous benefits, including the capability to mitigate regulatory risk, improve study participants’ comprehension, and provide a more efficient way of collecting consent, therefore saving time and money.