BioCrystal, Ltd. Commercializes New Cell Separation Technology For Use With OptiCell

Columbus, OH - OptiCell places desired cells in a fluid population in close proximity to new, technically advanced high field magnet technology, resulting in purer separations with higher positive and negative yields in single use applications.

In controlled single-use laboratory experiments using OptiCell's new magnet technology in combination with 1-micron size avidin-conjugated Dynabeads, the purity of the negatively selected cell population was greater than 95%, as verified by flow cytometry. Recovery yields were greater than 99% for both the negative and positive cell populations.

OptiCell can be used to perform in situ magnetic cell selection under conditions that minimize the effects of cell viability degradation. OptiCell offers the means to separate or isolate cells, culture the selected cells, and harvest the scaled up cell population in the same sterile environment.

OptiCell's patented design and construction make it the ideal tool for cell culture and subsequent procedures including in situ microscopy, time lapse studies, in situ immunocytostaining, transfections, single-cell cloning, and shipping live cells - direct from incubator to mailer to incubator. Cells are in contact with media at all times, facilitating OptiCell's use in automated cell culture practices. OptiCell offers the ability to separate and scale up a selected cell population in the same sterile environment. OptiCell is also well suited for continuous, laboratory-scale antibody production.

BioCrystal will collaborate with others in developing bioreagent-coupled OptiCell products that offer the means to simplify and streamline cell culture practices. BioCrystal will feature OptiCell at the AACR Meeting in Washington DC April 1-5.

SOURCE: BioCrystal, Ltd.