Article | October 18, 2024

Cheat-Sheet For Developing Innovative Bone Grafts

By Nadia Sharma, M.E.Sc.

DSM

Bone grafting is a rapidly expanding field. In developing new bone grafts, traditional materials such as ceramics, inductive growth factors, bioglass, autograft, and allograft are often employed. Traditional materials like autograft and allograft often face limitations such as limited supply, donor site morbidity, and potential disease transmission while other traditional bone graft materials lack inductivity or they may migrate from the repair site. To address these challenges, medical device companies are exploring innovative biomaterials. The Biomedical division of dsm-firmenich has developed an Extracellular Bone Matrix (EBM) platform that offers a promising solution. EBM is derived from young, healthy porcine bone and exhibits inductive properties*, offering the potential for improved handling, and the possibility of more predictable regeneration due to minimized donor-to-donor variability. Studies have demonstrated that EBM can induce novel bone formation in vivo without the need for exogenous factors.* This flexible platform can also be combined with other materials to create unique bone grafts, potentially improving patient outcomes and quality of life. (* data on file at Biomedical)

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