In order for digital pathology to achieve its full potential as a type of invitro-diagnostic that can streamline the overall pathology process, motion systems supporting high quality and high-speed imaging are essential. High reliability is also essential, and with anything else, minimizing the overall size of the instrument(s) is ideal. Because automated pathology scanners require unique positioning, off-the-shelf components rarely make for a proper motion solution. Packaging challenges can also become apparent, and product consistency can prove to be a difficult to achieve. This white paper offers key considerations that one should contemplate when designing a pathology scanning stage or working with a motion control partner.