Overcoming The Challenges Of Depyrogenation Of Class III Devices

Companies that produce class III devices are required to have both sterilization and depyrogenation for their products. Pyrogens are endotoxins derived from a purified lipopolysaccharide layer in the cell wall of bacteria that is released into the surrounding environment during bacterial death, lysis, or multiplication. They can cause a rise in body temperature or more serious complications when released into the bloodstream.  Because pyrogens are toxins and not bacteria, they can be present in a sterile product, and therefore require specific methods of depyrogenation. Download the full article to see how REVOX sterilization is able to achieve depyrogenation at a safe temperature due to the oxidizing and antimicrobial properties of peracetic acid.