Tissues And Complex Materials Why Toxicology-Chemistry Collaboration Matters

This webinar explores the unique challenges of chemically characterizing and toxicologically evaluating complex medical device materials. Presenters examine difficult matrices — including animal, human, and plant-derived tissues, hydrogels, absorbable devices, silicone implants, and drug-containing systems — and how their composition and behavior can complicate standard biocompatibility testing.

The session underscores why early, ongoing collaboration between analytical chemists and toxicologists is essential to fit-for-purpose study design. Topics include ISO 10993-based testing strategies, extraction conditions, and dose-based threshold setting, along with the role of feasibility studies in addressing solvent compatibility and material absorption. Speakers also address particulate formation, non-volatile residue interpretation, and the limits of analytical detection for large or complex molecules.

Drawing on real-world examples and regulatory insights, the webinar shows how integrated study design — backed by the right analytical techniques and clear cross-disciplinary communication — can strengthen toxicological risk assessments and regulatory outcomes. Attendees will leave with practical guidance for designing chemical characterization studies that reflect actual clinical use conditions and meet evolving regulatory expectations for an increasingly complex device landscape.