Tissues, Complex Materials: Why Toxicology-Chemistry Collaboration Matters

This video explores the challenges of chemically characterizing and toxicologically evaluating complex medical device materials — from tissues and hydrogels to absorbable devices, silicone implants, and drug-containing systems — and how these materials can complicate standard biocompatibility testing.

It highlights why close collaboration between analytical chemists and toxicologists is essential to designing fit-for-purpose studies, touching on ISO 10993 strategies, extraction conditions, and threshold setting. Using real-world examples and regulatory insights, it shows how integrated study design leads to stronger risk assessments and better regulatory outcomes.