Article | January 19, 2023

Understanding mRNA Technology As A Platform For Biopharma

Source: Roche CustomBiotech

Synthetic messenger RNA (mRNA) is a new platform technology for biopharma companies with attractive opportunities in therapeutics, gene therapy or vaccine applications. The straightforward adaptation of mRNA to specific and even personalized targets promises to usher in breakthroughs in precision medicine. The in vitro synthesis of mRNA using bacteriophage RNA polymerases like T7 or SP6 obviates the need to culture cells and extract proteins from a crude cell mass through elaborate purification steps. This simplified, cell-free manufacturing process is scalable and easily adopted within a short time.

Explore the advantages of mRNA technology, the process steps of large-scale mRNA production, and the effect of common contaminants on mRNA manufacturing.

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