With more than 60 years of experience in formulation of quality aqueous cleaners, Alconox, Inc. understands the cleaning needs of the pharmaceutical industry, including stringent FDA regulations and GMP compliance. Pharmaceutical processing professionals need safe, effective, and easy to validate cleaners for manual, machine wash, and clean-in-place applications for removing difficult to clean residues like titanium dioxide, petrolatum, and tablet coating residues.
Alconox, Inc. has a range of 12 products, which vary from high emulsifying to low foaming and powder to liquid. Alconox aqueous cleaners are ideal for a variety of cleaning applications including ultrasonic, clean in place, machine, and parts washer.
The experts at Alconox formulate all cleaners to be biodegradeable, readily disposable, and free rinsing to leave no interfering residues.
Sizes range from single gallon and four-pound boxes to drums, ideal for scaling from the research and development stage to large-scale manufacturing.
All cleaner brands are GMP compliant and have lot specific COA, technical bulletins, and material safety data sheets.
Alconox brands are manufactured in the United States and are sold through leading distributors in the laboratory, healthcare, and industrial fields in more than 40 countries.
30 Glenn St., Suite 309
White Plains, NY 10603
Contact: Jeff Phillips
The principal concern for any scientist or technician working in the laboratory is that glassware, instruments, and equipment be free of interfering residues.
The use of aqueous cleaning in medical device manufacturing can provide numerous benefits in terms of efficacy, minimal surface contact and reduced residue potential, and easier cleaning validation.
Getting the best results from any cleaner requires proper mixing and cleaning procedures. This article includes mixing directions for aqueous cleaning detergent and methods for monitoring performance.
The use of aqueous cleaning in pharmaceutical manufacturing can provide numerous benefits in terms of effectiveness, minimal surface residue, and easier cleaning validation.
Cleaning validation or verification is a necessary regulatory compliance step in medical device manufacturing and reprocessing. Support from the cleaner manufacturer can save time and money.
Cleaning validation is a necessary and time-consuming part of manufacturing pharmaceuticals. The validation process can be expedited and cost reduced if the cleaner supplier can provide support.
For cleanroom cleaning, users should consider liquid concentrate detergents to avoid the creation of powdered clouds in the classified environment.
Q. What does free rinsing detergent mean?
A faster and more efficient method to remove silicone grease from syringes is to use very hot water for cleaning and very hot water for rinsing.
It is very important to pay attention to how glassware and equipment is loaded in to a washer so as to minimize trapping any water from cycle to cycle.
Q. What kind of cleaner options can you provide which can be safely be used in stainless steel dishwashers?
Q. We are interested in Alconox® detergent for cleaning during our production process. Since we produce several kinds of medicine, we need to be sure Alconox® do not leave any residue after cleaning. We want to test the residue of Alconox® by UV method or HPLC method. Could you send reference or guide on these methods?
Q. Can I use pH paper to confirm cleaning and rinsing of labware to comply with lab accreditation requirements?
Dissolved oxygen and pH probes used in fermentation vessels can get buildup from the fermentation media that degrades the probe performance and increases the likelihood of batch to batch contamination.
As a rule of thumb, alkaline detergents are best for organic, oily residues, while acidic detergents are best for inorganic residue like salts and oxides.
When beginning cleaning validation, a company must identify the residues to be tested and then select the best detection method.
This technical note from Alconox discusses the best way to monitor for bath life extension in medical device cleaning, and it includes a step-by-step guide to the process.
Nanotechnology is currently employed across a wide range of industrial, research, and academic applications. Stringent cleaning protocols are essential to the successful fabrication of nanotechnology particles, structures, and systems.
Today's aqueous critical-cleaning detergents are blended for specific applications. Substrate, degree of soil load, and cleaning processes are all important considerations when selecting a detergent.
This white paper outlines the basics of cleaning validation and the role that the cleaner manufacturer can play in simplifying, speeding up, and supporting the maintenance of cleaning validation.